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Level International
Plastic types Microplastics Nanoplastics
Funding source European Union SOCIETAL CHALLENGES - Health, demographic change and well-being
Project cost 5.999.571,25 EUR
Period April 2021 - March 2025
Geographical area Europe
Categories Alternative Testing Methods Human Exposure Public Health Air Quality and Greenhouse Gases Water Food and Feed Safety
Tags Microplastic Nanoplastic exposure risk health long-term
Project partners
  • Wageningen University (WUR) - Netherlands,
  • Technical University of Denmark (DTU) - Denmark,
  • Commissariat A L Energie Atomique Et Aux Energies Alternatives - France,
  • Asociacion De Investigacion De Materiales Plasticos Y Conexas (Aimplas) - Spain,
  • Helmholtz-Centre for Environmental Research (UFZ) - Germany,
  • Leipzig University - Germany,
  • Tyoterveyslaitos - Finland,
  • Fundación para la Formación e Investigación Sanitarias de la Región de Murcia (FFIS) - Spain,
  • The University Of Manchester - United Kingdom,
  • Institut national de la santé et de la recherche médicale (Inserm) - France

Innovative approaches to shed light on the health impact of micro- and nanoplastics: Information about the potential effects of micro- and nanoplastics (MNPLs) on humans is scarce. On top of this, current methodologies are unable to provide appropriate exposure and risk assessments. The EU-funded PLASTICHEAL project aims to develop new methodologies and reliable scientific evidence for regulators to set the knowledge basis for adequate risk assessment of MNPLs. It will investigate the impact and consequences of MNPLs on human health, drawing a variety of experimental human models and measuring potential health effects under short and long-term conditions.

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Knowledge Gaps

Environmental fate and behavior of plastic

Characteristics of plastic-general

Commercial-related uncertainties

Environmental risk assessment (ERA)

Risk assessment (RA)


Mode of action (MOA)

Toxicokinetics, toxicodynamics and metabolism (ADME)

Human and environmental effects and toxicity test methods



Chronic or long-term effects, multiple forms and/or sources

Environmental effects and ecotoxicity

Environmental exposure

Consumer exposure

Human and environmental exposure test methods

Carcinogenicity test methods

Genotoxicity test methods

Testing considerations-general

Unspecific uncertainties

Models to predict toxicity

Species and individual susceptibility

Reproductive and teratogenic effects


Human toxicity

Mutagenicity test methods

Cellular uptake of plastic

Extrapolation of data


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