- Wageningen University (WUR) - Netherlands,
- Technical University of Denmark (DTU) - Denmark,
- Commissariat à l'énergie atomique et aux énergies alternatives (CEA) - France,
- Asociacion De Investigacion De Materiales Plasticos Y Conexas (Aimplas) - Spain,
- Helmholtz-Centre for Environmental Research (UFZ) - Germany,
- Leipzig University - Germany,
- Tyoterveyslaitos - Finland,
- Fundación para la Formación e Investigación Sanitarias de la Región de Murcia (FFIS) - Spain,
- The University Of Manchester - United Kingdom,
- Institut national de la santé et de la recherche médicale (Inserm) - France
Innovative approaches to shed light on the health impact of micro- and nanoplastics: Information about the potential effects of micro- and nanoplastics (MNPLs) on humans is scarce. On top of this, current methodologies are unable to provide appropriate exposure and risk assessments. The EU-funded PLASTICHEAL project aims to develop new methodologies and reliable scientific evidence for regulators to set the knowledge basis for adequate risk assessment of MNPLs. It will investigate the impact and consequences of MNPLs on human health, drawing a variety of experimental human models and measuring potential health effects under short and long-term conditions.
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Knowledge Gaps
Environmental fate and behavior of plastic
Characteristics of plastic-general
Commercial-related uncertainties
Environmental risk assessment (ERA)
Risk assessment (RA)
Genotoxicity
Mode of action (MOA)
Toxicokinetics, toxicodynamics and metabolism (ADME)
Human and environmental effects and toxicity test methods
Carcinogenicity
Degradation
Chronic or long-term effects, multiple forms and/or sources
Environmental effects and ecotoxicity
Environmental exposure
Consumer exposure
Human and environmental exposure test methods
Carcinogenicity test methods
Genotoxicity test methods
Testing considerations-general
Unspecific uncertainties
Models to predict toxicity
Species and individual susceptibility
Reproductive and teratogenic effects
Neurotoxicity
Human toxicity
Mutagenicity test methods
Cellular uptake of plastic
Extrapolation of data